Asian stocks were in the red on Tuesday as surging Covid-19 cases in China hit the confidence of investors who are already worried about the Ukraine war and the first US interest rate rise in three years, which could come this week.
MSCI's broadest index of Asia-Pacific shares outside Japan was down 1.91 per cent, led by Chinese stocks. The index is down 8.2 per cent so far this month.
Hopes that talks between Russia and Ukraine due to resume on Tuesday could provide a resolution to the conflict prompted a sharp fall in global oil prices.
However, the fourth round of negotiations began Monday with no major progress seen, adding to the nervousness in equity markets.
During the Asian session, US crude slipped a further 2.54 per cent to $100.44 a barrel, in line with broader asset selling. Brent crude was down 2.27 per cent to $104.42 per barrel.
In US trading, oil prices had fallen as much as 5.8 per cent as prospects of a positive outcome in Ukraine talks eased concerns about major supply disruptions.
But adding to the overall negative sentiment are rising case numbers of Covid-19 in China, which investors fear will hurt the mainland's economic growth in the first quarter.
"Right now everyone is looking at the Chinese cases and realising that has to have an effect on production," said Hong Hao, BOCOM International's head of research.
"China's growth in the first quarter could be closer to zero than 5.5 per cent. There's a ripple effect. There's Ukraine, the risk of US sanctions on China and rising Chinese domestic Covid cases - it does not look good."
Hong Kong's Hang Seng Index remains mired in negative territory, dropping 3.8 per cent early on Tuesday, following an almost 5 per cent selloff one day earlier. Hong Kong's main board is down 17 per cent so far in March.
China's CSI300 index was down 2.3 per cent.
China on Tuesday reported 3,602 new confirmed coronavirus cases compared with 1,437 on Monday, according to the National Health Commission.
Investor focus is also on the US Federal Reserve, which meets on Wednesday and is expected to hike interest rates for the first time in three years to offset rising inflation.
Australian shares slipped 0.5 per cent while Tokyo's Nikkei Index was marginally higher, up 0.17 per cent.
US stocks experienced a mixed session, with declining technology companies prompting most indexes to close lower Monday.
The Dow Jones Industrial Average was mostly flat, the S&P 500 lost 0.74 per cent and the Nasdaq Composite dropped 2.04 per cent.
The yield on the benchmark 10-year Treasury notes rose to 2.1419 per cent compared with its US close of 2.14 per cent on Monday.
The two-year yield, which rises with traders' expectations of higher Fed fund rates, touched 1.865 per cent, up from 1.849 per cent.
Gold was also weaker in Asia with the spot price at $1,949.21 per ounce.