India will need to bat out the final day of the fourth Test against Australia in Brisbane to retain the Border-Gavaskar Trophy.
Steve Smith made 55 as the hosts were dismissed for 294, setting India an unlikely 328 to win at the Gabba.
The impressive Mohammed Siraj took 5-73 and Shardul Thakur 4-61 for an injury-depleted India.
Openers Rohit Sharma and Shubman Gill led India to 4-0 before rain ended play early.
Australia scored quickly on the penultimate day, motivated by a bad weather forecast and a desire to put the game out of India's reach.
While India could still win, it is more likely that they will need to survive a minimum of 98 overs on Tuesday to ensure a 1-1 series draw.
(Source: BBC)